Cao Lab at CWRU - PUBLICATIONS

Publications (most updated list can be found at Google scholar:

42. Panoramic photoacoustic computed tomography with learning-based classification enhances breast lesion characterization

Xin Tong‡, Cindy Z. Liu‡, Yilin Luo‡, Li Lin‡, Jessica Dzubnar, Marta Invernizzi, Stephanie Delos Santos, Yide Zhang, Rui Cao, Peng Hu, Junfu Zheng, Jaclene Torres, Armine Kasabyan, Lily L. Lai, Lisa D. Yee, Lihong V. Wang, Nature Biomedical Engineering (2025)

41. Transcranial photoacoustic tomography de-aberrated using boundary elements

K. Sastry‡, Y. Aborahama‡, Y. Luo, Y. Zhang, M. Cui, R. Cao, G. Ku, LV. Wang, IEEE Transactions on Medical Imaging (2025)

40. Optical-resolution parallel ultraviolet photoacoustic microscopy for slide-free histology

R. Cao, Y. Luo, J. Zhao, Y. Zeng, Y. Zhang, Q. Zhou, A. le da Zerda, LV. Wang, Science Advances, 10, 10:ado0518. (2024)

39. Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

N. Sun, YY. Sun, R. Cao, HR. Chen, Y. Wang, E. Fugate, M. Smucker, YM. Kuo, P. Grant, D. Lindquist, CY. Kuan, S. Hu, eLife, under revision.

38. Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector

Y. Zhang‡, P. Hu‡, L. Li, R. Cao, A. Khadria, K. Maslov, X. Tong, Y. Zeng, L. Jiang, Q. Zhou, LV. Wang, Nature Biomedical Engineering, 8, 712–725 (2024) (Highligthed by Nature Biomedical Engineering News and Views)

37. Quantum imaging of biological organisms through spatial and polarization entanglement

Y. Zhang‡, Z. He‡, X. Tong‡, D. Garrett, R. Cao, LV. Wang, Science Advances, 10, 10: 2eadk1495. (2024)

36. Single-shot 3D photoacoustic computed tomography with a densely packed array for transcranial functional imaging

R. Cao‡, Y. Luo‡, J. Xu, X. Luo, K. Geng, Y. Aborahama, M. Cui, S. Davis, S. Na, X. Tong, C. Liu, K. Sastry, K. Maslov, P. Hu, Y. Zhang, L. Lin, Y. Zhang, LV. Wang, arXiv Preprint: 2306.14471. (2023)

35. Effects of Acute and Endurance Exercise on Cerebrovascular Function and Oxygen Metabolism: A Photoacoustic Microscopy Study

Y. Wang, N. Sun, I. Milne, R. Cao, Q. Liu, Z. Li, Y. Guan, Z. Yan, S. Hu, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 70, 12: 1651. (2023)

34. Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia

A. Khadria, C. Paavola, K. Maslov, P. Brown-Augsburger, P. Grealish, M. Lozano, R. Blankenship, R. Cao, J. Shi, J. Beals, S. Oladipupo, LV. Wang, Journal of Biomedical Optics, 28, 11: 116002. (2023)

33. A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption

H. Assi, R. Cao, M. Castelino, B. Cox, F. Gilbert, J. Gröhl, K. Gurusamy, L. Hacker, A. Ivory, J. Joseph, F. Knieling, M. Leahy, L. Lilaj, S. Manohar, I. Meglinski, C. Moran, A. Murray, A. Oraevsky, M. Pagel, M. Pramanik, J. Raymond, M. Singh, W. Vogt, LV. Wang, S. Yang, Members of IPASC, S. Bohndiek, Photoacoustics, 32, 100539. (2023)

32. Optical-resolution photoacoustic microscopy with a needle-shaped beam

R. Cao‡, J. Zhao‡, L. Li, L. Du, Y. Zhang, Y. Luo, L. Jiang, S. Davis, Q. Zhou, A. de la Zerda, LV. Wang, Nature Photonics, 17 89–95. (2023) (Highlight by Nature)

31. Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy

R. Cao, S. Nelson, S. Davis, Y. Liang, Y. Luo, Y. Zhang, B. Crawford, LV. Wang, Nature Biomedical Engineering, 7, 2: 124-134. (2023)

30. Non-invasive photoacoustic computed tomography of rat heart anatomy and function

L. Lin‡, X. Tong‡, S. Cavallero, Y. Zhang, S. Na, R. Cao, T. Hsiai, LV. Wang, Light: Science & Applications, 12,1: 12. (2023)

29. Non-invasive three-dimensional photoacoustic tomography of angiographic anatomy and hemodynamics of rat fatty livers

X. Tong‡, L. Lin‡, P. Hu, R. Cao, LV. Wang, Advanced Science, 10, 2: 2205759. (2023)

28. Multi-bioinspired soft grasping actuator with laser-induced multi-scale microstructures

C. Zhang, L. Zhao, R. Chen, Q. Zhao, R. Cao, C. Wang, Y. Hu, D. Wu, Advanced Intelligent Systems, 4, 11: 2200103 (2022)

27. Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site

A. Khadria, C. Paavola, K. Maslov, F. Valenzuela, A. Sperry, A. Cox, R. Cao, J. Shi, P. Brown-Augsburger, E. Lozano, R. Blankenship, R. Majumdar, S. Bradley, J. Beals, S. Oladipupo, LV. Wang, Molecular Metabolism, 62, 101522. (2022)

26. Photoacoustic microscopy of vascular adaptation and tissue oxygen metabolism during cutaneous wound healing

N. Sun, A. Bruce, B. Ning, R. Cao, Y. Wang, F. Zhong, S. Peirce, S. Hu, Biomedical Optics Express 13, 5: 2695. (2022)

25. Rapid fabrication of microrings with complex cross section using annular vortex beams

C. Zhang, H. Ye, R. Cao, S. Ji, H. Zhang, L. Zhao, S. Wu, H. Zhai, Chinese Optics Letters, 20, 2: 023801. (2022) (Featured as cover)

24. Hemodynamic and oxygen-metabolic responses of the awake mouse brain to hypercapnia revealed by multi-parametric photoacoustic microscopy

R. Cao, A. Tran, J. Li, Z. Xu, N. Sun, Z. Zuo, S. Hu, Journal of Cerebral Blood Flow and Metabolism, 41, 10: 2628. (2021)

23. Development of a photoacoustic microscopy technique to assess peritubular capillary function and oxygen metabolism in the mouse kidney

N. Sun, S. Zheng, D. Rosin, N. Poudel, J. Yao, H. Perry, R. Cao, M. Okusa, S. Hu, Kidney International, 100, 3: 613-620. (2021) (Featured as cover).

22. Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy

V. Sciortino‡, A. Tran‡, N. Sun‡, R. Cao, T. Sun, Y. Sun, P. Yan, F. Zhong, Y. Zhou, C. Kuan, J. Lee, S. Hu, Journal of Cerebral Blood Flow and Metabolism, 41, 12: 3187-3199. (2021)

21. High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

L. Lin‡, P. Hu‡, X. Tong‡, S. Na‡, R. Cao, X. Yuan, D. Garrett, J. Shi, K. Maslov, LV. Wang, Nature Communication, 12, 1: p1-10. (2021)

20. Rapid fabrication of high-resolution multi-scale microfluidic devices based on the scanning of patterned femtosecond laser

C. Zhang, J. Zhang, R. Chen, J. Li, C. Wang, R. Cao, J. Zhang, H. Ye, H. Zhaia, K. Sugiokae, Optics Letters, 45, 14: 3929-3932. (2020)

19. Wave of single-impulse–stimulated fast initial dip in single vessels of mouse brains imaged by high-speed functional photoacoustic microscopy

Y. He, J. Shi, K. Maslov, R. Cao, LV. Wang, Journal of Biomedical Optics, 25, 6: 066501. (2020)

18. In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network

N. Sun, B. Ning, A. Bruce, R. Cao, S. Seaman, T. Wang, R. Fritsche-Danielson, L. Carlsson, S. Peirce, S. Hu, Microcirculation, 27 (3). (2020) (Featured as cover).

17. Photoacoustic microscopy of obesity-induced cerebrovascular alternations

R. Cao, J. Li, C. Zhang, Z. Zuo, S. Hu, Neuroimage, 188, 369-379. (2019)

16. Cortex-wide multi-parametric photoacoustic microscopy based on real-time contour scanning

Z. Xu, N. Sun, R. Cao, Z. Li, Q. Liu, S. Hu, Neurophotonics, 6, 3: 035012. (2019)

15. Comprehensive characterization of cerebrovascular dysfunction in blast traumatic brain injury using photoacoustic microscopy

R. Cao‡, C. Zhang‡, V. Mitkin, M. Lankford, J. Li, Z. Zuo, C. Goyne, C. Meyer, J. Stone, S. Hu, Journal of Neurotrauma, 36 , 10: 1526-1534. (2019)

14. Photoacoustic microscopy reveals the role of sphingosine-1-phosphate induced neuroprotection against ischemic stroke

R. Cao, J. Li, Y. Kharel, C. Zhang, K. Lynch, Z. Zuo, S. Hu, Theranostics, 8, 22 :6111-6120. (2018) (Featured as cover).

13. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

S. Mesquita‡, A. Louveau‡, A. Vaccari, I. Smirnov, R. Cornelison, K. Kingsmore, C. Contarino, S. Onengut-Gumuscu, E. Farber, D. Raper, K. Viar, R. Powell, W. Baker, N. Dabhi, R. Cao, S. Hu, S. Rich, J. Munson, M. Lopes, C. Overall, S. Acton, J. Kipnis, Nature, 560, 7717, 185. (2018) (Featured as cover; One of most notable advance in 2018 by NIH).

12. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

A. Louveau, J. Herz, M. Alme, G. Herod, J. Setliff, K. Viar, S. Mesquita, D. Raper, A. Salvador, I. Smirnov, R. Cao, S. Hu, C. Overall, G. Oliver, J. Kipnis, Nature Neuroscience, 21, 10, 1380. (2018) (Featured as cover)

11. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers

A. Norambuena, H. Wallrabe, R. Cao, D. Wang, A. Silva, Z. Svindrych, S. Hu, R. Tanzi, D. Kim, G. Bloom, The EMBO Journal, e100241. (2018)

10. Dictionary learning-based reverberation removal enables depth-resolved photoacoustic microscopy of cortical microvasculature in the mouse brain

S. Sathyanarayana, B. Ning, R. Cao, S.Hu, J. Hossack, Scientific Reports, 8, 1: 985. (2018)

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