Deep Tissue Optical Imaging
Photoacoustic imaging stands out in deep tissue imaging due to its dual use of optical and ultrasonic properties. This method harnesses the contrast capabilities of optical imaging and the deep penetration of ultrasound. Unlike traditional imaging techniques, photoacoustic imaging offers detailed visualization deep within tissues, without the need for invasive procedures. This unique combination enables it to effectively identify vascular structures and pathologies, making it an invaluable tool in biomedical research and clinical diagnostics.
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Deep-learning Assisted Label-free Histology
Recent advancements in ultraviolet photoacoustic histology have provided new opportunities for the intraoperative histology. This technique enables real-time, three-dimensional imaging of thick tissue without the need for sectioning. Its integration with an neural network for virtual staining aids pathologists in quickly identifying cancerous features. Its ability to accurately determine tumor margins during surgery marks a significant step forward in oncology.
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Photoacosutic Micrscopy of Brain Disorders
Photoacoustic microscopy (PAM) is a key technology in advancing brain imaging, especially in the study of cerebral hemodynamics and metabolic dynamics. Recent research highlights its effectiveness in observing changes in brain oxygenation, particularly under anesthesia, and its importance in studying neurological conditions such as stroke and Alzheimer's Disease. PAM's non-invasive, high-resolution imaging capabilities provide essential insights into the brain's vascular and metabolic functions, offering a significant tool for neuroscience research and potential disease intervention.
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Hemodynamics and Metabolic Functional Imaging
Photoacoustic imaging is pivotal in hemodynamics and metabolic functional imaging, offering label-free insights into vasculature, oxygen metabolism and blood flow. It enables the visualization and quantification of oxygenated and deoxygenated hemoglobin, key in assessing tissue vascular function and metabolic states. This technique is particularly valuable for studying changes in blood flow and oxygen transport in various pathophysiological conditions. Its high-resolution, non-invasive imaging provides crucial data for advancing diagnostic and therapeutic approaches in areas such as ischemic diseases and tumor analysis.
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